Kubvisa kupindwa muropa necocaine

Kubvisa kupindwa muropa necocaine

Masayendisiti paJohns Hopkins University vakawana nzira yaimbozivikanwa yekuita kwecocaine muuropi, iyo inogona kuvhura musuwo wekugadzira mhando nyowani dzekurapa kwekupindwa muropa nezvinodhaka, New Atlas inoshuma, ichitaura nepepanhau PNAS.

Cocaine receptors muuropi

Zvinonakidza kuti iyo yakawanikwa inoita seinoshanda zvakasiyana mumakonzo echirume neechikadzi. Cocaine inozivikanwa kudyidzana ne synapses muuropi, kudzivirira neurons kubva pakuwana dopamine, kemikari neurotransmitter inobatanidza nekunzwa kwemubairo uye mafaro. Dopamine buildup mumasynapses inoita kuti manzwiro akanaka agare kwenguva refu, achiteya vanonzwira tsitsi mukupindwa muropa necocaine.

Kutsvaga nzira dzekuvhara dhizaini iyi kwagara kwave kutaurwa senge ingangoita kurapwa kwekushandisa cocaine kusagadzikana, asi zvave zvakaoma kuziva chaiwo mareceptor anogona kunangana nemushonga. Protein inozivikanwa seye dopamine transporter DAT ndiyo yaive yakanyanya kujeka mumiriri, asi zvinozoitika kuti cocaine inosunga kwairi zvisina kusimba, zvinoreva kuti kuchine mareceptor akanyanya hukama hwecocaine isati yazivikanwa.

BASP1 receptor

Kuti izvi zviitike, vaongorori veJohns Hopkins vakaedza nembeva maseru europi akakurira mundiro yemurabhoritari uye akafumurwa kucocaine. Masero akaiswa pasi kuti aedzwe kuti aone mamorekuru akasungwa kune mashoma emushonga - uye receptor inonzi BASP1 yakamuka.

Zvadaro boka revatsvakurudzi rakagadzirisa majini emakonzo kuitira kuti aingova nehafu chete yehuwandu hwehuwandu hweBASP1 receptors munzvimbo yehuropi hwavo inonzi striatum, iyo inobata basa muhurongwa hwemubairo. Kana mbeva dzakapihwa madosi akaderera ecocaine, kutorwa kwakaderedzwa kusvika pahafu yehuwandu uchienzaniswa nemakonzo akajairwa. Vatsvagiri vanoratidzawo kuti maitiro emakonzo akagadziridzwa angangoita hafu yezinga rekukurudzira rinopihwa necocaine, zvichienzaniswa nembeva dzakajairwa.

Estrogen barrier

Solomon Snyder, munyori-munyori wekudzidza, akati izvi zvakawanikwa zvinoratidza kuti BASP1 ndiyo inogamuchira ine chekuita nemhedzisiro yecocaine, zvichireva kuti marapirwo ezvinodhaka anogona kutevedzera kana kuvhara iyo BASP1 receptor inogona kudzora mhinduro kucocaine kuti ibvise kupindwa muropa.

Vatsvakurudzi vakaona kuti mhedzisiro yekubvisa BASP1 inoratidzika kungoshandura mhinduro yekodineine mumakonzo echirume, nepo vakadzi vasina kuratidza misiyano mumafambiro zvichienderana nemazinga ekugamuchira, kunyanya sezvo BASP1 receptor inosunga kune yevakadzi hormone estrogen, iyo inogona kukanganisa iyo michina, saka boka rinoronga Kuwedzera kutsvagisa uye kuyedza kukunda chipingamupinyi ichi.

Vatsvagiri vanotarisira kuwana mishonga yekurapa inogona kuvhara cocaine inosunga kune BASP1 receptor, iyo inogona kupedzisira yatungamira kune mitsva marapirwo ekushandisa cocaine kusagadzikana.