Kuchotsa kuledzera kwa cocaine

Kuchotsa kuledzera kwa cocaine

Asayansi ku yunivesite ya Johns Hopkins apeza njira yomwe cocaine imagwirira ntchito muubongo, yomwe ingatsegule khomo lopangira mitundu yatsopano yamankhwala oledzera, New Atlas malipoti, potchulapo magazini ya PNAS.

Cocaine receptors mu ubongo

Ndizosangalatsa kuti njira yomwe yapezeka ikuwoneka kuti imagwira ntchito mosiyana ndi mbewa zazimuna ndi zazikazi. Cocaine amadziwika kuti amalumikizana ndi ma synapses muubongo, kuletsa ma neuron kuti asatenge dopamine, mankhwala ophatikizika amanjenje omwe amalumikizidwa ndi malingaliro a mphotho ndi chisangalalo. Kuchulukana kwa dopamine mu ma synapses kumapangitsa kuti malingaliro abwino azikhala kwanthawi yayitali, kutsekereza omvera muzokonda za cocaine.

Kupeza njira zoletsera makinawa kwakhala akunenedwa kuti ndi njira yothanirana ndi vuto la kugwiritsa ntchito cocaine, koma zakhala zovuta kuzindikira ma receptor omwe mankhwalawa amatha kulunjika. Puloteni yomwe imadziwika kuti dopamine transporter DAT ndiyomwe idadziwika bwino kwambiri, koma zidapezeka kuti cocaine imamangiriridwa mofooka, zomwe zikutanthauza kuti pali ma receptor omwe amalumikizana kwambiri ndi cocaine omwe sanadziwikebe.

BASP1 cholandilira

Kuti izi zitheke, ofufuza a Johns Hopkins adayesa ma cell a ubongo wa mbewa omwe amakulira m'mbale ya labotale ndikukhala ndi cocaine. Maselo adayikidwa kuti ayesedwe mamolekyu enaake omangika pang'ono pamankhwala - ndipo cholandirira chotchedwa BASP1 chidapezeka.

Kenako gulu la ochita kafukufuku linasintha majini a mbewa kotero kuti amakhala ndi theka la kuchuluka kwanthawi zonse kwa BASP1 zolandilira m'chigawo chaubongo chawo chotchedwa striatum, chomwe chimagwira ntchito pamakina olipira. Pamene mbewa zinapatsidwa mlingo wochepa wa cocaine, kuyamwa kunachepetsedwa kufika theka la kuchuluka kwake poyerekeza ndi mbewa wamba. Ofufuzawo akuwonetsanso kuti machitidwe a mbewa osinthidwawo ndi pafupifupi theka la chilimbikitso choperekedwa ndi cocaine, poyerekeza ndi mbewa wamba.

Chotchinga cha Estrogen

Solomon Snyder, wolemba nawo kafukufukuyu, adati zomwe zapezazi zikuwonetsa kuti BASP1 ndiye cholandilira chomwe chimayambitsa cocaine, kutanthauza kuti mankhwala omwe amatha kutsanzira kapena kuletsa cholandilira cha BASP1 amatha kuwongolera mayankho ku cocaine kuti athetse chizolowezi.

Ofufuzawo adawona kuti zotsatira za kuthetsa BASP1 zikuwoneka kuti zimangosintha kuyankha kwa cocaine mu mbewa zamphongo, pomwe akazi sanawonetse kusiyana kulikonse pamakhalidwe otengera ma receptor, makamaka popeza BASP1 receptor imamangiriza ku mahomoni achikazi a estrogen, omwe amatha kusokoneza. limagwirira, kotero gulu likukonzekera Zambiri kafukufuku ndi zoyeserera kuthana ndi chopingachi.

Ofufuza akuyembekeza kupeza mankhwala achire omwe amatha kuletsa cocaine kumangiriza ku BASP1 receptor, zomwe pamapeto pake zitha kubweretsa chithandizo chatsopano cha vuto la kugwiritsa ntchito cocaine.