Tau tshem ntawm kev quav yeeb quav tshuaj

Tau tshem ntawm kev quav yeeb quav tshuaj

Cov kws tshawb fawb ntawm Johns Hopkins University tau tshawb pom yav dhau los tsis paub txog kev ua yeeb yaj kiab ntawm cov yeeb yaj kiab hauv lub hlwb, uas tuaj yeem qhib qhov rooj rau kev tsim kho tshiab rau kev quav yeeb tshuaj, New Atlas cov ntawv ceeb toom, hais txog phau ntawv xov xwm PNAS.

Cocaine receptors nyob rau hauv lub hlwb

Nws yog qhov nthuav tias qhov kev tshawb pom tau tshwm sim ua haujlwm sib txawv hauv cov nas txiv neej thiab poj niam. Cocaine paub tias cuam tshuam nrog synapses hauv lub hlwb, tiv thaiv cov neurons los ntawm kev tau txais dopamine, tshuaj neurotransmitter cuam tshuam nrog kev xav ntawm nqi zog thiab kev zoo siab. Lub buildup ntawm dopamine nyob rau hauv lub synapses ua rau cov kev xav zoo nyob ntev, cuab kev sympathizers mus rau yeeb tshuaj yeeb.

Nrhiav txoj hauv kev los thaiv cov txheej txheem no tau ntev tau npaj siab los ua qhov kev kho mob rau kev siv yeeb dawb, tab sis nws tau nyuaj los txheeb xyuas cov receptors tshwj xeeb uas cov tshuaj tuaj yeem tsom. Ib qho protein hu ua dopamine transporter DAT yog tus neeg sib tw pom tseeb tshaj plaws, tab sis nws hloov tawm tias cov yeeb yaj kiab khi rau nws kuj tsis muaj zog, uas txhais tau hais tias tseem muaj cov receptors muaj kev sib raug zoo rau cov yeeb yaj kiab uas tseem tsis tau txheeb xyuas.

BASP1 receptor

Txog rau qhov kawg no, cov kws tshawb fawb Johns Hopkins tau sim nrog nas hlwb hlwb loj hlob hauv chav kuaj zaub mov thiab raug tshuaj yeeb dawb. Cov hlwb tau muab tso rau hauv av kom kuaj xyuas cov molecules tshwj xeeb khi rau me me ntawm cov tshuaj - thiab cov receptor hu ua BASP1 tig.

Tom qab ntawd pab pawg ntawm cov kws tshawb fawb tau tweaked cov noob ntawm nas kom lawv tsuas muaj ib nrab ntawm cov nyiaj ib txwm muaj ntawm BASP1 receptors nyob rau hauv ib cheeb tsam ntawm lawv lub hlwb hu ua striatum, uas plays lub luag hauj lwm hauv cov khoom plig. Thaum cov nas tau txais cov tshuaj yeeb dawb tsawg, qhov nqus tau raug txo kom txog li ib nrab ntawm qhov piv rau cov nas ib txwm. Cov kws tshawb fawb tseem qhia tias cov nas hloov pauv tus cwj pwm yog li ntawm ib nrab ntawm qib kev txhawb nqa los ntawm cov yeeb tshuaj, piv rau cov nas ib txwm muaj.

Estrogen barrier

Solomon Snyder, tus kws tshawb fawb co-sau, tau hais tias cov kev tshawb pom no qhia tias BASP1 yog lub luag haujlwm rau cov tshuaj yeeb dawb, hais tias cov tshuaj kho mob uas tuaj yeem ua rau lossis thaiv BASP1 receptor tuaj yeem tswj cov lus teb rau yeeb tshuaj kom tshem tawm kev quav yeeb quav tshuaj.

Cov kws tshawb fawb tau sau tseg tias cov txiaj ntsig ntawm kev tshem tawm BASP1 zoo nkaus li tsuas yog hloov cov lus teb rau cov tshuaj yeeb dawb hauv cov txiv neej nas, thaum cov poj niam tsis pom qhov sib txawv ntawm tus cwj pwm raws li qib receptor, tshwj xeeb tshaj yog txij li BASP1 receptor khi rau poj niam cov tshuaj estrogen, uas tuaj yeem cuam tshuam nrog. lub tshuab, yog li pab neeg no npaj ntau kev tshawb fawb thiab kev sim kom kov yeej qhov teeb meem no.

Cov kws tshawb fawb vam tias yuav nrhiav tau cov tshuaj kho mob uas tuaj yeem thaiv cov yeeb yaj kiab los ntawm BASP1 receptor, uas tuaj yeem ua rau muaj kev kho tshiab rau kev siv yeeb dawb.