Kawar da cutar ta hodar iblis

Kawar da cutar ta hodar iblis

Masana kimiya a jami’ar Johns Hopkins sun gano wata hanyar da ba a san ta ba a kwakwalwar hodar iblis, wadda za ta iya bude kofar samar da sabbin nau’o’in maganin shaye-shayen miyagun kwayoyi, in ji jaridar New Atlas, da ta buga jaridar PNAS.

Masu karɓar maganin cocaine a cikin kwakwalwa

Yana da ban sha'awa cewa tsarin da aka gano ya bayyana yana aiki daban-daban a cikin mice maza da mata. An san Cocaine don yin hulɗa tare da synapses a cikin kwakwalwa, yana hana neurons samun dopamine, wani sinadari mai kwakwalwa da ke hade da jin dadi da jin dadi. Ginawar dopamine a cikin synapses yana sa jin daɗin rayuwa ya daɗe, yana kama masu tausayawa cikin jarabar cocaine.

An dade ana ba da shawarar gano hanyoyin da za a toshe wannan hanyar a matsayin yuwuwar maganin cutar ta cocaine, amma yana da wahala a gano takamaiman masu karɓa waɗanda maganin zai iya kaiwa hari. Wani furotin da aka sani da mai jigilar dopamine DAT shine ɗan takara mafi bayyananne, amma ya zama cewa cocaine yana ɗaure shi da rauni sosai, wanda ke nufin har yanzu akwai masu karɓa sosai ga cocaine waɗanda har yanzu ba a gano su ba.

BASP1 mai karɓa

Don haka, masu bincike na Johns Hopkins sun yi gwaji da ƙwayoyin kwakwalwar linzamin kwamfuta da aka girma a cikin kwanon dakin gwaje-gwaje kuma an fallasa su da hodar iblis. Kwayoyin sun kasance ƙasa don a gwada su don takamaiman ƙwayoyin cuta da ke daure da ƙananan adadin magungunan - kuma mai karɓa mai suna BASP1 ya fito.

Daga nan sai tawagar masu binciken suka yi gyare-gyaren kwayoyin halittar beraye ta yadda suka kunshi rabin adadin masu karban BASP1 da aka saba yi a wani yanki na kwakwalwarsu da ake kira striatum, wanda ke taka rawa a tsarin lada. Lokacin da aka bai wa mice ƙananan allurai na hodar iblis, an rage sha zuwa kusan rabin adadin idan aka kwatanta da ɓeraye na yau da kullun. Masu binciken sun kuma ba da shawarar cewa halayen berayen da aka gyara sun kai kusan rabin matakin kuzarin da cocaine ke bayarwa, idan aka kwatanta da berayen na yau da kullun.

Katangar estrogen

Solomon Snyder, marubucin marubucin binciken, ya ce waɗannan binciken sun nuna cewa BASP1 shine mai karɓan da ke da alhakin tasirin cocaine, yana nuna cewa magungunan ƙwayoyi wanda zai iya kwatanta ko toshe mai karɓar BASP1 na iya daidaita martani ga cocaine don kawar da jaraba.

Masu binciken sun lura cewa sakamakon kawar da BASP1 yana bayyana kawai canza martani ga cocaine a cikin mice maza, yayin da mata ba su nuna wani bambance-bambance a cikin hali dangane da matakan masu karɓa ba, musamman tun lokacin da mai karɓar BASP1 ya ɗaure ga hormone estrogen na mace, wanda zai iya tsoma baki tare da shi. tsarin, don haka ƙungiyar ta tsara ƙarin bincike da gwaje-gwaje don shawo kan wannan cikas.

Masu bincike suna fatan samun magungunan warkewa waɗanda za su iya toshe haɗin cocaine ga mai karɓar BASP1, wanda a ƙarshe zai iya haifar da sabbin jiyya don rashin amfani da hodar iblis.